Changes in Appetite and Unexplained Weight Loss:
Kidney disease can affect appetite and lead to unintended weight loss. As kidney function declines, waste products accumulate in the bloodstream, causing nausea, vomiting, and loss of appetite. Additionally, altered taste perception and metallic taste in the mouth, often associated with uremia (a condition resulting from kidney failure), can further diminish dietary intake. Unexplained weight loss, particularly in the absence of intentional dietary changes or increased physical activity, should prompt evaluation for underlying renal dysfunction.

Persistent Itching and Skin Rash:
Pruritus, or persistent itching, is a common yet distressing symptom of kidney disease. Accumulation of waste products such as urea in the bloodstream can irritate nerve endings in the skin, leading to generalized itching. Furthermore, mineral and electrolyte imbalances associated with kidney dysfunction may contribute to dryness, inflammation, and skin rash. Individuals experiencing persistent itching, especially in the absence of dermatological conditions, should consider kidney function assessment as part of their diagnostic evaluation.